PIM447 (hydrochloride)
CAS No. : 1210416-52-6
(Synonyms: LGH447 hydrochloride; PIM-447 hydrochloride; PIM 447 hydrochloride; LGH-447 hydrochloride; LGH 447 hydrochloride)
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| Cat. No. : | HY-19322A |
| M.Wt: | 1000.00 |
| Formula: | C24H23F3N4O.xClH |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase. target: pan-PIM inhibitor [2] [3] In vitro: PIM447 is cytotoxic for myeloma cells due to cell cycle disruption and induction of apoptosis mediated by a decrease in phospho-Bad (Ser112) and c-Myc levels and the inhibition of mTORC1 pathway. PIM447 also inhibits in vitro osteoclast formation and resorption, downregulates key molecules involved in these processes and partially disrupts the F-actin ring, while increasing osteoblast activity and mineralization.[1] In vivo: PIM447 significantly reduces the tumor burden and preventes tumor-associated bone loss in a disseminated murine model of human myeloma.[1]
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