Nelarabine
CAS No. : 121032-29-9
(Synonyms: 506U78; GW 506U78; Nelzarabine)
| Size | Price | Stock |
|---|---|---|
| 50mg | $84 | In-stock |
| 100mg | $120 | In-stock |
| 250mg | $195 | In-stock |
| 1g | $480 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-13701 |
| M.Wt: | 297.27 |
| Formula: | C11H15N5O5 |
| Purity: | >98 % |
| Solubility: | H2O : 10 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Nelarabine (506U78) is a nucleoside analogue and can be used for the research of T cell acute lymphoblastic leukemia (T-ALL)[1].
In Vitro: Nelarabine (506U78) (0-20 μM; 48 h) induces cytotoxic effects in T-ALL cell lines[1].
Nelarabine (5 or 2 μM; 48 h) promotes apoptosis in sensitive T-ALL cell lines and modulates PI3K/AKT/mTOR and MEK signaling[1].
Nelarabine (10 μM; 0-48 h) resistance does not depend on expression of ENT1/2 transporters and is partly due to upregulation of PI3K, MEK, and Bcl2 signaling[1].
In Vivo: Nelarabine (506U78) (130 mg/kg/day; i.v.; 5 days) reduces leukemic burden and extends mouse survival in NSG mice xenografted with luciferase-expressing U937 cells[2].
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