Simvastatin acid
CAS No. : 121009-77-6
(Synonyms: Tenivastatin)
| Size | Price | Stock |
|---|---|---|
| 1mg | $350 | In-stock |
| 5mg | $970 | In-stock |
| 10mg | $1185 | In-stock |
| 25mg | $1520 | In-stock |
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| Cat. No. : | HY-119695 |
| M.Wt: | 436.58 |
| Formula: | C25H40O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].
IC50 & Target:HMG-CoA reductase, Reactive oxygen species[1][2]
In Vitro:Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells[2].
Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells[2].
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