Terreic acid
CAS No. : 121-40-4
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| Cat. No. : | HY-110013 |
| M.Wt: | 154.12 |
| Formula: | C7H6O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Terreic acid, a quinone epoxide antibiotic, acts as an effective Btk inhibitor. Terreic acid blocks the interaction between PKC and the pleckstrin homology domain of Btk. Terreic acid inhibits the binding of GST-BtkPH to PKC in lysates of HMC-1 human mast cells with an IC50 of approximately 100 μM[1].
IC50 & Target: Btk; Antibiotic[1]
In Vitro: Terreic acid inhibits the association of Btk with PKCβII in mouse mast cells at lower concentrations (IC50 of ≈30 μM). Terreic acid inhibits the catalytic activity of Btk but not PKC[1].
Terreic acid (pretreatment for 30 min before stimulation by antigen for 3 min) inhibits both the basal and activation levels of Btk autophosphorylating activity with IC50s of 10 μM and 3 μM, respectively[1].
Terreic acid inhibits the autophosphorylating activity of Btk purified partially from recombinant baculovirus-infected Sf9 insect cells in a dose-dependent manner[1].
In Vivo: Terreic acid inhibits the late-phase response of in vivo allergic cutaneous reactions[1].
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