3-Deazaneplanocin A (hydrochloride) (GMP)
CAS No. : 120964-45-6
(Synonyms: DZNep (hydrochloride) (GMP); NSC 617989 (hydrochloride) (GMP); 3-Deazaneplanocin (hydrochloride) (GMP))
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| Cat. No. : | HY-12186G |
| M.Wt: | 298.73 |
| Formula: | C12H15ClN4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
3-Deazaneplanocin A (DZNep) hydrochloride (GMP) is 3-Deazaneplanocin A hydrochloride (HY-12186) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. 3-Deazaneplanocin A hydrochloride is a potent histone methyltransferase EZH2 inhibitor[1][2].
In Vitro: 3-Deazaneplanocin A (20-200 nM, during 16-28 day) stimulates Oct4 expression in chemically induced pluripotent stem cells (CiPSCs)[2].
3-Deazaneplanocin A (20-200 nM, during 16-28 day) inhibits DNA and H3K9 methylation at the Oct4 promoter in CiPSCs[2].
3-Deazaneplanocin A (10 nM, 24 h) promotes developmental competence of cloned pig embryos[3].
3-Deazaneplanocin A (10 nM, 24 h) decreases the levels of H3K27me3 and H3K9me2 at the 2-cell, 4-cell and blastocyst stages[3].
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