N6022
CAS No. : 1208315-24-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $119 | In-stock |
| 10mg | $185 | In-stock |
| 50mg | $554 | In-stock |
| 100mg | $911 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-14984 |
| M.Wt: | 414.46 |
| Formula: | C24H22N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
N6022 is a potent, selective, reversible, and efficacious S-Nitrosoglutathione reductase(GSNOR) inhibitor with IC50 of 8 nM. IC50 & Target: IC50: 8 nM (GSNOR)[2] In Vitro: N6022 shows concentration-dependent binding to rat plasma proteins. N6022 has more effect on ATP at lower drug concentrations (20 μM) than on GSH[1]. N6022 binds in the GSNO substrate binding pocket like a competitive inhibitor with an IC50 of 8 nM and a Ki of 2.5 nM. N6022 is uncompetitive with cofactors NAD+ and NADH[2]. In Vivo: N6022 (50 mg/kg)-treated rats show a slight increase in the incidence of granulomas. In serum, N6022 remains in solution up to 5 mg/mL[1].
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