Ibrexafungerp
CAS No. : 1207753-03-4
(Synonyms: MK 3118; SCY-078)
| Size | Price | Stock |
|---|---|---|
| 1mg | $220 | In-stock |
| 5mg | $570 | In-stock |
| 10mg | $920 | In-stock |
| 25mg | $1850 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-107126 |
| M.Wt: | 730.03 |
| Formula: | C44H67N5O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp can be used for research of Candida and Aspergillus infections[1].
In Vitro: Ibrexafungerp leads to fungicidal activity against various Candida spp., with MIC of 0.5 µg/mL[2].
Ibrexafungerp is effective against C. albicans, C. krusei, C. parapsilosis with MICs of 0.06, 0.5, 0.25 µg/mL[5].
In Vivo: Ibrexafungerp (p.o., 10 mg/kg) is effective against C. auris in an guinea pig cutaneous infection model[4].
Ibrexafungerp (p.o., mouse 1 mg/kg, rat 5 mg/kg and dog 5 mg/kg) exhibits oral bioavailability (mouse 51%, rat 45%, dog 35%)[3].
Ibrexafungerp (i.v., mouse 1 mg/kg, rat 5 mg/kg and dog 5 mg/kg) exhibits moderate half-lives (mouse 5.5, rat 8.7 and, dog 9.3 h) due to high plasma clearance (0.68, 0.44, and 0.45 L/h/kg respectively)[3].
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