(rac)-Talazoparib
CAS No. : 1207454-56-5
(Synonyms: (rac)-BMN-673; (rac)-LT-673)
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| Cat. No. : | HY-14687 |
| M.Wt: | 380.35 |
| Formula: | C19H14F2N6O |
| Purity: | >98 % |
| Solubility: |
(rac)-Talazoparib ((rac)-BMN-673) (Compound 47) is the orally active inhibitor for PARP1/2 with Ki of 1.2 nM and 0.87 nM. (rac)-Talazoparib inhibits cellular PARylation with an EC50 of 2.51 nM. (rac)-Talazoparib causes the accumulation of DNA damage, inhibits proliferation of BRCA1/2-mutated MX-1 cell and Capan-1 cell with IC50 of 0.3 nM and 5 nM. (rac)-Talazoparib exhibits antitumor efficacy in mouse models[1].
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