Fesoterodine (L-mandelate)
CAS No. : 1206695-46-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $85 | In-stock |
| 25mg | $142 | In-stock |
| 50mg | $200 | In-stock |
| 100mg | $290 | In-stock |
| 500mg | $560 | In-stock |
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| Cat. No. : | HY-70053A |
| M.Wt: | 563.72 |
| Formula: | C34H45NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Fesoterodine L-mandelate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine L-mandelate is used for the overactive bladder (OAB)[1][2].
IC50 & Target: pKi: 8.0 (M1), 7.7 (M2), 7.4 (M3), 7.3 (M4) and 7.5 (M5)[3]
In Vitro: Fesoterodine L-mandelate decreases micturition frequency, urgency severity and urgency incontinence episodes and increases the volume voided with each micturition[1].
After oral administration, Fesoterodine L-mandelate is rapidly and extensively hydrolysed in plasma by nonspecific esterases to Desfesoterodine (5-hydroxymethyl tolterodine; SPM 7605; HY-76569; an active metabolite of Fesoterodine)[3][4].
In Vivo: Fesoterodine L-mandelate (0.01-1 mg/kg; IV) reduces the micturition pressure and increases bladder capacity and ICIs (intercontraction intervas) at the lowest dose tested of 0.01 mg/kg[3].
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