(RS)-PPG
CAS No. : 120667-15-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $115 | In-stock |
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| 10 mg | Get quote | |
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| Cat. No. : | HY-107514 |
| M.Wt: | 231.14 |
| Formula: | C8H10NO5P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(RS)-PPG is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity[1]. IC50 & Target: EC50: 5.2 μM (hmGluR4a), 4.7 μM (hmGluR6), 185 μM (hmGluR7b), and 0.2 μM (hmGluR8a)[1] In Vitro: Activation of group III mGluRs by treatment of neurons with (R,S)-PPG (100 μM) can significantly suppress the elevation of intracellular calcium and protect neurons from apoptosis induced by Aβ[31-35] (25 μM)[2].
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