Mofegiline (hydrochloride)
CAS No. : 120635-25-8
(Synonyms: MDL72974A)
| Size | Price | Stock |
|---|---|---|
| 5mg | $192 | In-stock |
| 10mg | $308 | In-stock |
| 25mg | $616 | In-stock |
| 50mg | $987 | In-stock |
| 100mg | $1580 | In-stock |
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| Cat. No. : | HY-16677A |
| M.Wt: | 233.69 |
| Formula: | C11H14ClF2N |
| Purity: | >98 % |
| Solubility: | H2O : 25 mg/mL (ultrasonic);DMSO : 110 mg/mL (ultrasonic) |
Mofegiline hydrochloride (MDL72974A) is an orally active and selective enzyme-activated irreversible inhibitor of MAO-B, with marked selectivity on the MAO-B over MAO-A with IC50s of 3.6 nM (MAO-B) and 680 nM (MAO-A), respectively. Mofegiline hydrochloride is also an inhibitor of semicarbazide-sensitive amine oxidase (SSAO)[1][2][3].
IC50 & Target:IC50: 3.6 nM (MAO-B), 680 nM (MAO-A)[1]
In Vitro:Mofegiline hydrochloride (MDL72974A) inhibits rat brain mitochondrial MAO in a concentration and time-dependent fashion[1].
Mofegiline hydrochloride (MDL72974A) inhibits [3H]dopamine (15 nM) uptake with an IC50 value of 31.8 μM, but poorly inhibits [3H]GBR-12935 (1 nM) binding (IC50 >100 μM) in the rat striatum[2].
Mofegiline hydrochloride (MDL72974A) inhibits SSAOs from dog aorta, rat aorta, bovine aorta and human umbilical artery with IC50s of 2 nM, 5 nM, 80 nM and 20 nM, respectively[3].
In Vivo:Mofegiline hydrochloride (MDL72974A) (0.1-2.5 mg/kg; p.o.; single dose) inhibits MAO-B activity external vivo in rat model and (1.25 mg/kg; i.p.; 18 hours prior to MPTP treatment) exerts its ability to block MPTP neurotoxicity in mice model[1].
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