TC-Mps1-12
CAS No. : 1206170-62-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $175 | In-stock |
| 5mg | $520 | In-stock |
| 10mg | $880 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-110115 |
| M.Wt: | 324.38 |
| Formula: | C17H20N6O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM[1].
IC50 & Target: IC50: 6.4 nM (Mps1)[1]
In Vitro: TC-Mps1-12 inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay[1].
TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner and with an IC50 values of 0.84 μM[1].
In Vivo: TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells in a dose-dependent manner in vivo. At a dose of 100 mg/kg, TC-Mps1-12 exhibits 47% tumor growth inhibition without body weight loss[1].
TC-Mps1-12 shows good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg[1].
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Inquiry Information- Product Name:
- TC-Mps1-12
- Cat. No.:
- HY-110115
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