LEQ506
CAS No. : 1204975-42-7
(Synonyms: NVP-LEQ506)
| Size | Price | Stock |
|---|---|---|
| 5mg | $460 | In-stock |
| 10mg | $680 | In-stock |
| 25mg | $1160 | In-stock |
| 50mg | $1560 | In-stock |
| 100mg | $2100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-18636 |
| M.Wt: | 432.56 |
| Formula: | C25H32N6O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. IC50 & Target: IC50: 2 nM (human smo), 4 nM (mouse smo)[1] In Vitro: LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. LEQ506 inhibits Hedgehog (Hh) signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2[1]. LEQ506 is an efficacious compound by consistently decreasing Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and of 60 to 70% for Ptch1[2].
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