(±)-Vesamicol (hydrochloride)
CAS No. : 120447-62-3
(Synonyms: (±)-AH5183 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $65 | In-stock |
| 10mg | $98 | In-stock |
| 25mg | $195 | In-stock |
| 50mg | $285 | In-stock |
| 100mg | $420 | In-stock |
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| Cat. No. : | HY-B1813A |
| M.Wt: | 295.85 |
| Formula: | C17H26ClNO |
| Purity: | >98 % |
| Solubility: | DMSO : 14 mg/mL (ultrasonic;warming;heat to 60°C) |
(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (±)-Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively[1][2]. IC50 & Target: Ki: 2 nM (Vesicular acetylcholine transport), 26 nM (σ1 receptors) and 34 nM (σ2 receptors)[1] In Vitro: The pharmacological actions of (±)-Vesamicol have been attributed to inhibition of acetylcholine transport into synaptic vesicles and the subsequent quantal release of acetylcholine[1]. In Vivo: (±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum[2].
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