TMC647055
CAS No. : 1204416-97-6
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| Cat. No. : | HY-15591 |
| M.Wt: | 606.73 |
| Formula: | C32H38N4O6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TMC647055 is a potent nonnucleoside NS5B polymerase inhibitor of HCV replication. TMC647055 has potent HCV combine activity with an IC50 value of 82 nM. TMC647055 can be used for the research of Hepatitis C virus (HCV)[1][2].
IC50 & Target:EC90: 0.3 μM (Huh7-Luc cell)[1].
EC50: 82 nM (HCV)[2]
In Vitro: TMC647055 has antiviral activity with an EC90 value of 0.3 μM in Huh7-Luc cells[1].
TMC647055 has potent combine activity with an EC50 value of 82 nM in cellular HCV assays[2].
In Vivo: TMC647055 (compound 18a) (2 mg/kg, iv.; 10mg/kg, po.) shows an acceptable PK profile, characterized by high oral bioavailability and high systemic exposure after single oral dosing of 10 mg/kg, combined with a moderate plasma clearanceand low volume of distribution[2].
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