σ1 Receptor antagonist-1
CAS No. : 1204401-49-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $105 | In-stock |
| 10mg | $165 | In-stock |
| 25mg | $352 | In-stock |
| 50mg | $572 | In-stock |
| 100mg | $935 | In-stock |
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| Cat. No. : | HY-10815 |
| M.Wt: | 337.48 |
| Formula: | C21H23NOS |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells[1]. In Vitro: σ1 Receptor antagonist-1 (compound 9) (10 μM; 48 hours) inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells[1]. In Vivo: Pretreatment withσ1 Receptor antagonist-1 (1 mg/kg; s.c.) significantly increases the anti-nociceptive effect produces by morphine over the entire time course starting at 60 min[1].
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