AZD1208
CAS No. : 1204144-28-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $86 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $480 | In-stock |
| 200mg | $630 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-15604 |
| M.Wt: | 379.48 |
| Formula: | C21H21N3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor[1]. In Vitro: AZD1208 shows good antiproliferative activity in a megakaryoblastic leukemia cell line, MOLM-16, with GI50 values less than 100 nM[1]. AZD1208 (10 μM) inhibits the growth of Ramos cells, and at 1 μM, strongly inhibits PIM kinases in all cell at 1 μM. AZD1208 induces apoptosis, and PIM2 knockdown is mainly associated with an alteration of the cell cycle[2]. The combination of AZD1208 and AZD2014 rapidly activates AMPKα, a negative regulator of translation machinery through mTORC1/2 signaling in AML cells; profoundly inhibits AKT and 4EBP1 activation; and suppresses polysome formation[3].
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