Isopropyl unoprostone
CAS No. : 120373-24-2
(Synonyms: Unoprostone isopropyl ester; UF-021)
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| Cat. No. : | HY-109545 |
| M.Wt: | 424.61 |
| Formula: | C25H44O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca2+-activated K+ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity[1][2].
IC50 & Target: BK channels[1]
In Vitro: Isopropyl unoprostone (0.01-1 μM; 24 h) protects against H2O2-induced 661W cell death[2].
Isopropyl unoprostone (0.1-3 μM; 24 h) reduced the morphological change of 661W cells and protects against light-induced cell death[2].
Isopropyl unoprostone (0.001-1 μM; 48 h) suppresses light-induced phagocytotic dysfunction in ARPE-19 cells[2].
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