Cyclotraxin B
CAS No. : 1203586-72-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $170 | In-stock |
| 5mg | $360 | In-stock |
| 10mg | $590 | In-stock |
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| Cat. No. : | HY-P1178 |
| M.Wt: | 1200.37 |
| Formula: | C48H73N13O17S3 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Cyclotraxin B is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC50 of 0.30 nM. Cyclotraxin B has analgesic and anxiolytic effects[1][2][3].
In Vitro: Cyclotraxin B (1 pM-100 nM; 48 h) inhibits BDNF-induced neurite outgrowth in a dose-dependent manner with an IC50 of 12.9 pM, and significantly reduces the phosphorylation level of BDNF-induced MAPK in nnr5 PC12-TrkB cells[1].
In Vivo: Cyclotraxin B (intravenous injection; 2×200 μg; two times; with a 90-minute interval) has anxiolytic effects in mice[1].
Cyclotraxin B (intraperitoneal injection; 2×20 mg/kg; two times; with a 90-minute interval) can prevent and reverse cold allodynia induced by BDNF or infraorbital nerve ligation in mice[2].
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