CX-6258
CAS No. : 1202916-90-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $135 | In-stock |
| 25mg | $266 | In-stock |
| 50mg | $400 | In-stock |
| 100mg | $600 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-18095 |
| M.Wt: | 461.94 |
| Formula: | C26H24ClN3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
CX-6258 is a potent and kinase selective pan-Pim kinases inhibitor, with IC50s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively[1].
IC50 & Target: IC50: 5 nM (Pim-1), 25 nM (Pim-2), 16 nM (Pim-3)[1]
In Vitro: CX-6258 causes dose dependent inhibition of the phosphorylation of two pro-survival proteins, Bad and 4E-BP1, at the Pim kinase specific sites S112 and S65 and T37/46, respectively[1].
CX-6258 treatment (12 mM, 3 h) treatment diminishes steady-state levels of ectopic NKX3.1 in PC3 cells[2].
CX-6258 treatment results in a significant reduction in NKX3.1 half-life[2].
In Vivo: CX-6258 (50-100 mg/kg; p.o; daily; over a period of 21 days) exhibits robust in vivo efficacy in two Pim kinases driven tumor models[1].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- CX-6258
- Cat. No.:
- HY-18095
- Quantity:
Your information is safe with us.