CNX-774
CAS No. : 1202759-32-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $500 | In-stock |
| 100mg | $850 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13943 |
| M.Wt: | 499.50 |
| Formula: | C26H22FN7O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 45 mg/mL |
CNX-774 is an orally active, irreversible and selective BTK inhibitor, with an IC50 of < 1 nM. CNX-774 specifically targets Cysteine 481 of Btk for covalent modification[1][2].
IC50 & Target: IC50: 1 nM (BTK)[1].
In Vitro: CNX-774 strongly inhibits Btk activity in Ramos cells with an IC50 of 1-10 nM. CNX-774 demonstrates strong time- and dose-dependent occupancy of Btk in Ramos cells[1].
In Vivo: CNX-774 is stable and non-reactive in fresh human and rat whole blood and does not covalently bond to any of the mid-level abundance human plasma proteins[1].
CNX-774 demonstrates potent inhibitory activity towards the intended target, Btk, while achieving remarkable specificity in a variety of assays designed to assess off-target reactivity towards abundant cellular thiols and blood proteins[1].
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