PC-046
CAS No. : 1202401-59-9
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| Cat. No. : | HY-120561 |
| M.Wt: | 358.39 |
| Formula: | C22H18N2O3 |
| Purity: | >98 % |
| Solubility: |
PC-046 is a multi-target inhibitor for tyrosine receptor kinase B (TrkB), IRAK-4 and Pim-1, with IC50 of 13.4 μM, 15.4 μM and 19.1 μM, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC50 of 7.5-130 nM. PC-046 induces apoptosis and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice[1]. IC50 & Target:IC50: 13.4 μM (TrkB); 15.4 μM (IRAK-4); 19.1 μM (Pim-1)
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