Clopidogrel (hydrogen sulfate)
CAS No. : 120202-66-6
(Synonyms: (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate)
| Size | Price | Stock |
|---|---|---|
| 5g | $19 | In-stock |
| 25g | $78 | In-stock |
| 100g | $233 | In-stock |
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| Cat. No. : | HY-17459 |
| M.Wt: | 419.90 |
| Formula: | C16H18ClNO6S2 |
| Purity: | >98 % |
| Solubility: | H2O : 16.67 mg/mL (ultrasonic);DMSO : ≥ 46.7 mg/mL |
Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively[1]. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation[2]．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[5].
IC50 & Target: IC50: 18.2 nM (CYP2B6)[1].
IC50: 524 nM (CYP2C19)[1]
In Vitro: Clopidogrel (1.5 mM;12 and 24 hours) up-regulates the expression of TRIB3 and CHOP in a concentration- and time-dependent manner, as measured by real-time PCR and Western blot analysis[3].
Clopidogrel (1.5 mM; 24 hours) significantly induces human gastric epithelial cell (GES-1) apoptosis[3].
In Vivo: Clopidogrel (5 mg/kg) significantly inhibits thrombus formation compared with vehicle. Acetylsalicylic acid (0.15 mg/kg) can add to the antithrombotic effect of Clopidogrel in mice; Acetylsalicylic acid (0.6 mg/kg) blunts the antithrombotic effect of Clopidogrel[4].
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