BPKDi
CAS No. : 1201673-28-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $115 | In-stock |
| 5mg | $350 | In-stock |
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| Cat. No. : | HY-118052 |
| M.Wt: | 380.49 |
| Formula: | C21H28N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
BPKDi is an inhibitor of PKD. BPKDi inhibits three members of the PKD family, PKD1, PKD2, and PKD3, with IC50 values of 1 nM, 9 nM, and 1 nM, respectively. BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells[1].
In Vitro:BPKDi (1 μM, 30 min) significantly attenuates PMA (HY-18739) (25 nM)-induced auto-phosphorylation of PKD1 in neonatal rat ventricular myocytes (NRVMs)[1].
BPKDi (1 μM, 72 h) completely blocks agonist-dependent induction of myomaxin mRNA expression, supporting the notion that PKD derepresses MEF2 target genes via class IIa HDACs in myocytes[1].
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