Duvelisib
CAS No. : 1201438-56-3
(Synonyms: IPI-145; INK1197)
| Size | Price | Stock |
|---|---|---|
| 5mg | $77 | In-stock |
| 10mg | $110 | In-stock |
| 50mg | $209 | In-stock |
| 100mg | $343 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-17044 |
| M.Wt: | 416.86 |
| Formula: | C22H17ClN6O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 41 mg/mL |
Duvelisib (IPI-145) is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively[1][2]. IC50 & Target: IC50: 2.5 nM (p110δ), 27.4 nM (p110γ), 85 nM (p110β), 1602 nM (p110α)[2] In Vitro: PI3Kδ and PI3Kγ inhibition with Duvelisib (IPI-145) has anti-proliferative activity in primary AML cells by inhibiting the activity of AKT and MAPK. Pre-treatment of AML cells with Duvelisib inhibits both adhesion and migration of AML blasts to bone marrow stromal cells[1].
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