Atabecestat
CAS No. : 1200493-78-2
(Synonyms: JNJ-54861911)
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $640 | In-stock |
| 25mg | $1280 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-109052 |
| M.Wt: | 367.40 |
| Formula: | C18H14FN5OS |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction. Atabecestat s tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat has the potential for Alzheimer's Disease treatment[1]. IC50 & Target:IC50: BACE1[1] In Vivo:Atabecestat (100 and 300 mg/kg; p.o. once daily for 3 days) reduces the human Aβ levels in mice[2]. Atabecestat (300 mg/kg; p.o. once) inhibits the exacerbation of vascular abnormalities in APPPS1 mice with 3D6 treatment[2].
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