GDC-0425
CAS No. : 1200129-48-1
(Synonyms: RG-7602)
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $380 | In-stock |
| 100mg | $600 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19926 |
| M.Wt: | 321.38 |
| Formula: | C18H19N5O |
| Purity: | >98 % |
| Solubility: | H2O : 25 mg/mL (ultrasonic;adjust pH to 3 with HCl) |
GDC-0425 (RG-7602) is an orally available, highly selective small molecule ChK1 inhibitor. GDC-0425 can be used for the research of various malignancies[1][2].
In Vitro: MEK inhibition either by pharmacologic inhibitors or RNAi-mediated gene silencing significantly protected cells from reduced viability upon GDC-0425 treatment[3].
GDC-0425 (3 μM; 24 hours) treatment results the hyperphosphorylation of Chk1[3].
In Vivo: GDC-0425 exhibits partial suppression of tumor growth. The Gemcitabine/GDC-0425 combination results in significant tumor regression in all tested models[3].
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