GNE-900
CAS No. : 1200126-26-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $272 | In-stock |
| 25mg | $490 | In-stock |
| 50mg | $735 | In-stock |
| 100mg | $1102 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15883 |
| M.Wt: | 367.45 |
| Formula: | C23H21N5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C) |
GNE-900 is a an ATP-competitive, selective, and orally active ChK1 inhibitor with IC50s of 0.0011, 1.5 µM for ChKl, ChK2, respectively. GNE-900 abrogates the G2-M checkpoint, enhances DNA damage, and induces Apoptosis. gemcitabine (HY-17026) and GNE-900 administration shows anti-tumor activity[1]. In Vitro:GNE-900 (1 µM; 1-48 h) induces apoptosis with increases in the expression of cleaved PARP when combined with gemcitabine (50 nM) in HT-29 cells[1]. In Vivo:GNE-900 (2.5-40 mg/kg; p.o.; once) decreases the tumor volume and increases DNA damage, γ-H2AX levels when combinated with gemcitabine (HY-17026) in rats[1].
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