Donepezil (Hydrochloride)
CAS No. : 120011-70-3
(Synonyms: E2020)
| Size | Price | Stock |
|---|---|---|
| 25mg | $55 | In-stock |
| 50mg | $79 | In-stock |
| 100mg | $106 | In-stock |
| 200mg | $158 | In-stock |
| 500mg | $285 | In-stock |
| 1g | $410 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-B0034 |
| M.Wt: | 415.95 |
| Formula: | C24H30ClNO3 |
| Purity: | >98 % |
| Solubility: | H2O : 25 mg/mL (ultrasonic);DMSO : 6.2 mg/mL (warming) |
Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2].
In Vitro: Donepezil’s neuroprotective mechanism is related to the enhanced phosphorylation of Akt and GSK-3β and reduced phosphorylation of tau and glycogen synthase[2].
In Vivo: Donepezil treatment (3 mg/kg) significantly prevents the progression of scopolamine-induced memory impairment in mice[3].
A pharmacokinetic study of Donepezil shows a mean peak plasma concentration of donepezil after oral treatment (3 and 10 mg/kg) of approximately 1.2±0.4 h and 1.4±0.5 h, respectively; absolute bioavailability is calculated as 3.6%[3].
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