INT-777
CAS No. : 1199796-29-6
(Synonyms: S-EMCA)
| Size | Price | Stock |
|---|---|---|
| 5mg | $420 | In-stock |
| 10mg | $600 | In-stock |
| 25mg | $960 | In-stock |
| 50mg | $1350 | In-stock |
| 100mg | $1880 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15677 |
| M.Wt: | 450.65 |
| Formula: | C27H46O5 |
| Purity: | >98 % |
| Solubility: | Ethanol : ≥ 50 mg/mL;DMSO : ≥ 31 mg/mL |
INT-777 is a potent TGR5 agonist with an EC50 of 0.82 μM. IC50 & Target: EC50: 0.82 μM (TGR5)[1] In Vitro: INT-777 is a novel potent and selective TGR5 agonist with remarkable in vivo activity[1]. INT-777 (3 μM) increases ATP production in the human enteroendocrine cell line NCI-H716 in a cAMP-dependent manner[2]. INT-777 (10 μM) lowers Isc and increases TEER when added on the serosal side of seromuscular stripped distal colon segments. INT-777 effect on basal secretion is reduced in neuron-free and TTX-treated mucosal-submucosal preparations[3]. In Vivo: INT-777 (1 μM/min/kg, p.o.) has a potent choleretic effect, prevents carboxyl CoA activation and subsequent conjugation, thereby favoring its cholehepatic shunt pathway with a ductular absorption and a potent choleretic effect in HF-fed TGR5-Tg male mice[1]. INT-777 (30 mg/kg/day, p.o.) increases energy expenditure and reduces hepatic steatosis and obesity upon high fat feeding in TGR5-Tg mice[2].
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