GNE 220
CAS No. : 1199590-75-4
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| Cat. No. : | HY-U00428 |
| M.Wt: | 438.53 |
| Formula: | C25H26N8 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM. IC50 & Target: IC50: 7 nM (MAP4K4), 9 nM (MINK/MAP4K6), 476 nM (DMPK), 1.06 μM (MELK), 1.1 μM (KHS1/MAP4K5), 1.13 μM (TBK1), 2.02 μM (Flt3), 2.06 μM (Rse)[1] In Vitro: GNE-220 also inhibits a few other kinases with IC50s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+ retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+ long focal adhesions (FAs)[1].
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