Delequamine
CAS No. : 119905-05-4
(Synonyms: RS-15385-197)
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| 25mg | $2200 | Get quote |
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| Cat. No. : | HY-106874 |
| M.Wt: | 350.48 |
| Formula: | C18H26N2O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Delequamine (RS-15385-197) is an orally active and selective α2-adrenergic receptor antagonist with a pKi of 9.5 for α2-adrenoceptors in rat cortex. Delequamine shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine can be used for the study of erectile dysfunction[1]. In Vivo:Delequamine (0.4-6.4 mg/kg; oral, single dose) can increase the sexual behavior score in a dose-dependent manner in a model where untrained male rats are exposed to estrogen-progesterone-treated, sexually receptive female rats. Furthermore, the combination of Delequamine (0.4 mg/kg; oral, single dose) and 8-OH-DPAT (HY-112061) (0.1 mg/kg; subcutaneous injection) can increase the percentage of mounts, intromissions, and ejaculations in rats, shorten the ejaculation latency, and reduce the number of intromissions[1].
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