Liafensine
CAS No. : 1198790-53-2
(Synonyms: BMS-820836)
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| Cat. No. : | HY-19907 |
| M.Wt: | 366.46 |
| Formula: | C24H22N4 |
| Purity: | >98 % |
| Solubility: |
Liafensine (BMS-820836) is an orally active, blood-brain barrier-permeable monoamine reuptake inhibitor, with an IC50 of 5.67 nM against DAT, 1.08 nM against SERT, and 7.99 nM against NET. Liafensine binds to DAT to block dopamine reuptake. Liafensine binds to SERT to block serotonin reuptake. Liafensine binds to NET to block norepinephrine reuptake. Liafensine can be used in studies related to depression[1][2]. IC50 & Target:IC50: 1.08 nM (serotonin transporter), 5.67 nM (dopamine transporter), 7.99 nM (norepinephrine transporter) In Vitro:Liafensine potently inhibits monoamine reuptake in embryonic kidney 293 cells expressing SERT, DAT and NET, with IC50 values of 1.08 nM, 5.67 nM and 7.99 nM, respectively[1]. In Vivo:Liafensine (0.3 mg/kg) produces a 77% reduction in immobility in the mouse tail suspension model of depression[1].
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