LDN-211904 (oxalate)
CAS No. : 1198408-78-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $150 | In-stock |
| 5mg | $365 | In-stock |
| 10mg | $546 | In-stock |
| 25mg | $930 | In-stock |
| 50mg | $1256 | In-stock |
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| Cat. No. : | HY-107460 |
| M.Wt: | 444.87 |
| Formula: | C21H21ClN4O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LDN-211904 oxalate is a potent and reversible EphB3 inhibitor with an IC50 of 79 nM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with Cetuximab (HY-P9905) could be effective in inhibiting STAT3-activated colorectal cancer (CRC) stemness and Cetuximab resistance in CRC[1][2].
IC50 & Target:IC50: 0.079 µM (EphB3)[1]
In Vitro:LDN-211904 (20 μM; 24 h) oxalate induces apoptosis by increasing c-PARP in SW48 resistant cells[2].
LDN-211904 (20 μM; 4-20 h) oxalate decreases the levels of p-STAT3, GLI-1, SOX2 and Vimentin in SW48 resistant cells[2].
In Vivo:LDN-211904 (0.1 mg/kg; i.p.; three times a week; for 21 days) oxalate inhibits and overcomes Cetuximab (HY-P9905) resistance in vivo[2].
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