TAS-114
CAS No. : 1198221-21-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $70 | In-stock |
| 5mg | $210 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $650 | In-stock |
| 50mg | $980 | In-stock |
| 100mg | $1450 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124062 |
| M.Wt: | 451.54 |
| Formula: | C21H29N3O6S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
TAS-114 is an orally active dual dUTPase/dihydropyrimidine dehydrogenase (DPD) inhibitor, can improving the therapeutic efficacy of fluoropyrimidine[1].
IC50 & Target:dUTPase, DPD
In Vitro:TAS-114 (1-10 μM; 72 hours) increases the cytotoxicity of 5-Fluorouracil (5-FU) and 5-FU,2′-deoxy-5-fluorouridine (FdUrd) against various cancer cell lines in dose-dependent manner[1].
In Vivo:TAS-114 (37.5-1,200 mg/kg/day; orally; 1-14 days) increases the antitumor activity of 5-FU when co-administers with Capecitabine (539 mg/kg/day) in mice[1].
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