Dexloxiglumide
CAS No. : 119817-90-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $52 | In-stock |
| 25mg | $108 | In-stock |
| 50mg | $162 | In-stock |
| 100mg | $243 | In-stock |
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| Cat. No. : | HY-128878 |
| M.Wt: | 461.38 |
| Formula: | C21H30Cl2N2O5 |
| Purity: | >98 % |
| Solubility: |
Dexloxiglumide is an orally active and selective cholecystokinin type A (CCKA) receptor antagonist. Dexloxiglumide is the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8). Dexloxiglumide exhibits moderate Caco-2 permeability that is polarized, concentration dependent, and pH dependent. Dexloxiglumide increases MRP1-substrate fluorescein uptake. Dexloxiglumide can be studied in research for gastrointestinal diseases and tumors[1][2][3].
In Vitro:Dexloxiglumide (0-150 μM) activates P-gp ATPase in human membranes containing P-gp when concentration is above 17.3 μM[3].
Dexloxiglumide (433 μM) increases fluorescein uptake by 4-fold, suggesting inhibition of MRP1 efflux[3].
Dexloxiglumide (40 μM) demonstrates a reduced B/A ratio, suggesting a contribution of ATP-dependent efflux[3].
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