Mirin
CAS No. : 1198097-97-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $99 | In-stock |
| 25mg | $186 | In-stock |
| 50mg | $297 | In-stock |
| 100mg | $550 | In-stock |
| 200mg | $715 | In-stock |
| 500mg | $1300 | In-stock |
| 1g | $1950 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-19959 |
| M.Wt: | 220.25 |
| Formula: | C10H8N2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 31 mg/mL |
Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells[1][2].
In Vitro:Mirin (50, 100, 500 μM) inhibits ATM-dependent phosphorylation of Nbs1 and Chk2 and the MRN-dependent autophosphorylation of ATM at Ser1981 in response to DNA double-strand breaks (DSBs). Mirin (100 μM) inhibits Mre11 nuclease activity[1].
Mirin (10-100 μM; 24 h) shows 50% cytotoxicity at 50 μM in HEK293 cells[1].
Mirin (10-100 μM) induces a substantial G2 arrest at concentrations of 50 μM and 100 μM[1].
Mirin (18 µM; 48 h) increases apoptosis in PEO4 cells[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Mirin
- Cat. No.:
- HY-19959
- Quantity:
Your information is safe with us.