ALK-IN-1
CAS No. : 1197958-12-5
(Synonyms: Brigatinib analog)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $130 | In-stock |
| 50mg | $180 | In-stock |
| 100mg | $250 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13464 |
| M.Wt: | 529.01 |
| Formula: | C26H34ClN6O2P |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
ALK-IN-1 (Brigatinib analog) is an ALK and EGFR inhibitor. ALK-IN-1 binds to and inhibits ALK kinase, ALK fusion proteins, and wild-type and mutant EGFR variants, thereby disrupting their corresponding signaling pathways. ALK-IN-1 can suppress the growth and proliferation of tumor cells and exhibits potential inhibitory activity against mutant EGFR. ALK-IN-1 can be used in the research of non-small-cell lung cancer[1][2][3]. In Vivo:ALK-IN-1 (5 mg/kg; p.o.; single dose) exhibits a plasma AUC0-t of 262436.45 ng/mL·min, a brain AUC0-t of 23196.08 ng/g·min, and an AUCbrain/AUCplasma ratio of 0.088, confirming blood-brain barrier penetration[1].
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