BMS-814580
CAS No. : 1197420-11-3
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| Cat. No. : | HY-120608 |
| M.Wt: | 504.93 |
| Formula: | C24H19ClF2N2O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BMS-814580 is an orally active, highly efficacious MCHR1 inhibitor with a Ki of 16.9 nM against hMCHR1. BMS-814580 shows antiobesity activities[1].
IC50 & Target: Ki: 16.9 nM (MCHR1)[1]
In Vitro: BMS-814580 (3.0 μM; 10 min) shows stability with 90%, 95% and 100% remaining in human, rat and mouse liver microsomes, respectively[1].
BMS-814580 displays modest in vitro ion channel inhibition of 43%, 21%, and 15%, respectively, for hERG, Na (4 Hz), and L-type Ca channels at 10 μM[1].
In Vivo: BMS-814580 (0-3 mg/kg; p.o.; once daily for 28 days) shows antiobesity activities in rats[1].
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