UNC0224
CAS No. : 1197196-48-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $40 | In-stock |
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $260 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $760 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-10929 |
| M.Wt: | 485.67 |
| Formula: | C26H43N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic) |
UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 2.6 nM, an IC50 of 15 nM and a Kd of 23 nM. UNC0224 also potently inhibits b>GLP with assay-dependent IC50 values of 20-58 nM. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E[1][2].
In Vitro: In G9a ECSD and CLOT assays, the IC50 values of 43 nM and 57 nM for UNC0224 (Compound 10), respectively. In GLP ECSD and CLOT assays, the IC50 values of 50 nM and 58 nM for UNC0224, respectively. In ITC experiments, the Kd value of UNC0224 to the G9a protein is 23 nM[2].
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Inquiry Information- Product Name:
- UNC0224
- Cat. No.:
- HY-10929
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