Gedatolisib (Standard)
CAS No. : 1197160-78-3
(Synonyms: PKI-587 (Standard); PF-05212384 (Standard))
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| Cat. No. : | HY-10681R |
| M.Wt: | 615.73 |
| Formula: | C32H41N9O4 |
| Purity: | >98 % |
| Solubility: |
Gedatolisib (Standard) is the analytical standard of Gedatolisib. This product is intended for research and analytical applications. Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively[1]. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2[2].
IC50 & Target:IC50: 0.4 nM (PI3Kα), 5.4 nM (PI3Kγ), 1.6 nM (mTOR), 6 nM (PI3Kβ), 6 nM (PI3Kδ)[1]
mTORC1, mTORC2[3]
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