PF-3845
CAS No. : 1196109-52-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $73 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $265 | In-stock |
| 50mg | $430 | In-stock |
| 100mg | $688 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-14380 |
| M.Wt: | 456.46 |
| Formula: | C24H23F3N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH), with a Ki of 0.23 µM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition[1][3].
IC50 & Target: Ki: 0.23 µM (FAAH)[1]
In Vitro: PF-3845 (0.5 nM-10 μM; 40 min) inhibits human FAAH-1 (IC50=18 nM) in a concentration-dependent manner, and shows negligible activity against FAAH-2 (IC50>10 μM) in COS-7 cells[1].
PF-3845 (0.1-1000 μM; 48 h) significantly decreases the Colo-205 cell viability[2].
In Vivo: PF-3845 (1-30 mg/kg; p.o.) produces cannabinoid receptor-dependent reductions in inflammatory pain in rat[1].
PF-3845 (10 mg/kg; a single i.p.) selectively inhibits FAAH in mice for up to 24 hours[1].
PF-3845 (10 mg/kg; a single i.p.) causes a dramatic and sustained elevation in Anandamide (AEA) in mice[1].
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