ASP7657 (free base)
CAS No. : 1196045-28-9
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| Cat. No. : | HY-120598 |
| M.Wt: | 509.52 |
| Formula: | C28H26F3N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ASP7657 free base is an orally active EP4 receptor antagonist, with Kis of 2.21 and 6.02 nM for the human and rat EP4 receptors[1].
In Vitro:ASP7657 free base inhibits the PGE2-induced cAMP increase in CHO cells (expressing rat EP4 receptors) and human lymphoblastoid T cells, with IC50 values of 0.86 nM and 0.29 nM, respectively[1].
In Vivo:ASP7657 free base (0.1 mg/kg, p.o., rats) shows a t1/2 of 1.38 h, Cmax of 22.4 ng/mL, and oral bioavailability of 46.2%[1].
ASP7657 free base (0.003-0.1 mg/kg, p.o.) inhibits LPS (1 μg/mL)-induced TNF-α release from rat whole blood[1].
ASP7657 free base (0.01 mg/kg, p.o.) attenuates urinary albumin excretion in type 2 diabetic mice[1].
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