PRT-060318
CAS No. : 1194961-19-7
(Synonyms: PRT318)
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $380 | In-stock |
| 50mg | $620 | In-stock |
| 100mg | $990 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12974 |
| M.Wt: | 340.42 |
| Formula: | C18H24N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming;adjust pH to 3 with 1 M HCL;heat to 60°C);H2O : 25 mg/mL (ultrasonic) |
PRT-060318 (PRT318) s a potent, selective and orally active tyrosine kinase Syk inhibitor with an IC50 of 3 nM. PRT-060318 suppresses chronic lymphocytic leukemia (CLL) B cell activation and migration, and induces apoptosis. PRT-060318 prevents Heparin (HY-17567)-induced thrombocytopenia and thrombosis in a transgenic mouse model. PRT-060318 dihydrochloride can be used for CLL and thrombus research[1][2]. In Vitro:PRT-060318 (PRT318) (0-3 µM, 15 min) completely inhibits Heparin-induced thrombocytopenia (HIT) immune complex-induced aggregation of both human and transgenic HIT mouse platelets[1]. In Vivo:PRT-060318 (PRT318) (10 and 30 mg/kg, i.g., b.i.d. for 7 days) prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model[1].
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