Meropenem (trihydrate)
CAS No. : 119478-56-7
(Synonyms: SM 7338 trihydrate)
| Size | Price | Stock |
|---|---|---|
| 25mg | $45 | In-stock |
| 50mg | $72 | In-stock |
| 100mg | $108 | In-stock |
| 200mg | $150 | In-stock |
| 500mg | $255 | In-stock |
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| Cat. No. : | HY-13678A |
| M.Wt: | 437.51 |
| Formula: | C17H31N3O8S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 12.5 mg/mL (ultrasonic) |
Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL)[1][2]. In Vitro: Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia[2]. In Vivo: Meropenem (60 mg/kg; intraperitoneal injection; once; SD rats) treatment significantly reduces the incidence of pancreatic infection[3].
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