Danofloxacin (mesylate)
CAS No. : 119478-55-6
(Synonyms: CP 76136-27)
| Size | Price | Stock |
|---|---|---|
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| 50mg | $40 | In-stock |
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| 500mg | $186 | In-stock |
| 1g | $280 | In-stock |
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| Cat. No. : | HY-B0501 |
| M.Wt: | 453.48 |
| Formula: | C20H24FN3O6S |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone used as a veterinary drug. Danofloxacin mesylate has a broad spectrum of bactericidal activity, mainly inhibiting the DNA cycloenzyme of the bacteria. In addition, Danofloxacin mesylate is a substrate for ATP-dependent efflux transporters (P-gp and MRP2)[1][2][3].
In Vitro:Danofloxacin mesylate (1-25 μM; 1 h) transport across Caco-2 cells is asymmetric, with a rate of secretion exceeding that of absorption[1].
Danofloxacin mesylate (18 h) inhibits bovine bacterial respiratory pathogens with the MIC90 of 0.06-0.125 μg/mL for Pasteurella hemolyticus, Pasteurella multocida and Haemophilus somnosus[2].
In Vivo:Pharmacokinetic Analysis in geese[3]
| Route | Dose (mg/kg) (Non-salt dose) | AUC(0-t) (μg·h/mL) | AUC(0-inf) (μg·h/mL) | kel (1/h) | ka (1/h) | k10 (1/h) | k21 (1/h) | k12 (1/h) | t1/2kel (h) | Cmax (μg/mL) | Tmax (h) | Cl (mL/g·h) | V1 (mL/g) | V2 (mL/g) | F % |
| i.v. | 5 | 14.27 | 15.35 | 0.10 | / | 0.25 | 1.14 | 1.34 | 6.61 | / | / | 0.35 | 1.46 | 1.71 | / |
| p.o. | 5 | 8.30 | 9.14 | 0.17 | 0.32 | / | / | / | 4.12 | 0.96 | 1.70 | / | / | / | 57.95 |