Salviolone
CAS No. : 119400-86-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $310 | In-stock |
| 5mg | $620 | In-stock |
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| Cat. No. : | HY-122506 |
| M.Wt: | 268.35 |
| Formula: | C18H20O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells[1].
In Vitro: Salviolone (5-60 μM; 72 hours) reduces cell viability in the A375 and MeWo melanoma cell lines with EC50 values of 17 µM and 22 µM, respectively. Salviolone does not affect the growth of normal melanocytes[1].
Salviolone (20 μM; 48-72 hours) strongly reduces pRb, pCdk2, and cyclin A2, Tyr705-STAT3 phosphorylation expression levels in A375 cells. Salviolone also strongly increases the P21 and P53 protein expression level. Salviolone induces sustained activation of the phosphorylation of ERK1/2 and Akt[1].
Salviolone (10-20 μM) inhibits MMP2 gelatinase activity in the A375 melanoma cell line[1].
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