CRANAD-2
CAS No. : 1193447-34-5
| Size | Price | Stock |
|---|---|---|
| 100mg | $538 | In-stock |
| 250mg | $931 | In-stock |
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| Cat. No. : | HY-103242 |
| M.Wt: | 410.26 |
| Formula: | C23H25BF2N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 2.08 mg/mL (ultrasonic;warming;heat to 60°C);DMF : 2 mg/mL (ultrasonic;warming;heat to 60°C) |
CRANAD-2 is a specific near-infrared (NIR) fluorescent probe for detecting Aβ plaques (unbound to Aβ: Ex=640 nm; Em=805 nm; after binding: Em=715 nm). CRANAD-2 penetrates the blood-brain barrier and has high affinity for Aβ aggregates, with a Kd value of 38 nM. CRANAD-2 is applicable to research related to Alzheimer's disease and neurodegenerative diseases[1][2][3][4].
In Vitro:CRANAD-2 (0-1500 nM; 1 h) binds to preformed ΔN amyloid fibrils with a dissociation constant of 55 ± 6 nM[1].
CRANAD-2 (35 nM) enables SMLM super-resolution imaging of preformed ΔN amyloid fibrils at a concentration of 35 nM, with a resolution of 45-55 nm[1].
In Vivo:CRANAD-2 (2.0 mg/kg; i.v.; single dose) enables in vivo detection of Aβ deposits in the arcAβ mouse model via MSOT and epi-fluorescence imaging, with specific co-localization to Aβ deposits in brain sections[2].
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