LX7101
CAS No. : 1192189-69-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $195 | In-stock |
| 10mg | $320 | In-stock |
| 25mg | $680 | In-stock |
| 50mg | $1150 | In-stock |
| 100mg | $1890 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12659 |
| M.Wt: | 451.52 |
| Formula: | C23H29N7O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 150 mg/mL (ultrasonic) |
LX7101 is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 proves significantly selective for LIMK2 with IC50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 has the potential for ocular hypertension and associated glaucoma research[1][2].
In Vivo:LX7101 (200 μg/40 μL eye drop) displays a significant intraocular pressure (IOP) reduction at time points ranging from 1 h to 6 h post administration in ocular normotensive New Zealand White (NZW) rabbits[1].
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