Vibegron
CAS No. : 1190389-15-1
(Synonyms: MK-4618)
| Size | Price | Stock |
|---|---|---|
| 1mg | $230 | In-stock |
| 5mg | $590 | In-stock |
| 10mg | $950 | In-stock |
| 25mg | $1450 | In-stock |
| 50mg | $2030 | In-stock |
| 100mg | $2850 | In-stock |
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| Cat. No. : | HY-19933 |
| M.Wt: | 444.53 |
| Formula: | C26H28N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 95 mg/mL (ultrasonic) |
Vibegron (MK-4618) is a potent, highly selective and orally active β3-adrenoceptor agonist (EC50=1.1 nM). Vibegron can be used for severe urgency urinary incontinence related to overactive bladder[1][2][3].
IC50 & Target:EC50 : 1.1 nM (β3-adrenoreceptor)[3]
In Vivo:Vibegron (1~12 μΜ; i.v.) exhibits dose dependent decreases in micturition pressure and increases in functional bladder capacity[3].
Vibegron (30 mg/kg; p.o.; 4 weeks) upregulates mRNA levels of type 1, type 3 collagen, TGF‐β1, and HIF‐1α[4].
Vibegron (1 and 10 mg/kg; i.v.; interval 30 minutes) (10 mg/kg) in oxo-M-treated rats makes bladder capacity significantly decreased compared with oxo-M-not treated rats (intravesical instillation of vehicle)[5].
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